Myasthenia Gravis and Human Immunodeficiency Virus Infection:
Response to Intravenous Gamma Globulin and Prednisone
Strong and Douglas W. Zochodne
Background: There are only rare reports of myasthenia
gravis complicating human immunodeficiency virus infection.
The role of immunomodulatory therapy is unknown. Methods:
Case report and literature review. Results: The
diagnosis of human immunodeficiency virus infection followed
that of myasthenia gravis in a 35-year-old man. Clinical and
electrophysiological features were diagnostic of generalized
myasthenia gravis but two edrophonium chloride tests and acetylcholine
receptor antibodies were negative. Prednisone therapy and intravenous
gamma globulin were associated with rapid clinical recovery.
Conclusions: Prednisone therapy and intravenous
gamma globulin may be helpful in patients with generalized myasthenia
gravis complicating HIV infection.
J. Neurol. Sci. 1998; 25: 254-256